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MRD Testing in Pediatric and Adult ALL: Do Barriers Still Exist?

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Monitoring minimal residual disease (MRD) is recommended for measuring treatment response and predicting relapse in patients with acute lymphoblastic leukemia (ALL). Investigators for an Amgen-sponsored study surveyed US hematologists/oncologists who treat ALL patients about their use of MRD testing. Respondents included 150 physicians who mainly treat adult patients (67% in community settings and 33% in academic settings) and 30 physicians who mostly treat pediatric patients (33% in community settings and 67% in community settings). Overall, 93% of pediatric treaters and 73% of adult treaters said they tested MRD in patients at least once. Only half of adult treaters followed a standard pathway for MRD testing compared with 93% of pediatric treaters. Community-based adult treaters were least likely to conduct MRD testing. Both cohorts cited cost and insurance hurdles as common barriers to more frequent MRD testing.

Read more here.


Kim C, Delaney K, McNamara M, Chia V, Romanov V. Cross-sectional physician survey on the use of minimal residual disease testing in the management of pediatric and adult patients with acute lymphoblastic leukemia. Hematology. 2018;Aug 21:1-9. doi: 10.1080/10245332.2018.1510068.

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