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Congenital Cardiac Anomalies and Cleft Palate: Is There a Link?

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Several cardiac anomalies have been associated with cleft lip and palate, including rare cardiac diseases like Fallot’s tetralogy, Ebstein’s anomaly, hypoplastic left heart syndrome, and pulmonary atresia, but their prevalence in this setting has remained unclear. However, a 1-year retrospective review of medical records by Indian investigators found that among 200 patients with cleft lip and palate, 30 (15%) had associated congenital cardiac anomalies.

This is a retrospective study carried out for a period of one year. In the present study medical records of 200 patients with cleft lip and palate were evaluated and analyzed for presence of congenital cardiac anomalies. Associated congenital cardiac anomalies were most common among patients with unilateral cleft palate (21.05%), followed by those with unilateral cleft lip alveolus and palate (18.03%), bilateral cleft palate (16.67%), bilateral cleft lip alveolus and palate (15.87%), bilateral cleft lip (9.09%), and unilateral cleft lip (7.5%). Ventricular septal defect (36.6%) was the most commonly observed cardiac anomaly.

Read more here.


Kasatwar A, Borle R, Bhola N, K R, Prasad GSV, Jadhav A. Prevalence of congenital cardiac anomalies in patients with cleft lip and palate – Its implications in surgical management. J Oral Biol Craniofac Res. 2018;8(3):241-244. doi:10.1016/j.jobcr.2017.09.009.

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