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Nephrology

High-energy, low-protein formulas show promise as meal replacements for pre-dialysis CKD patients

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High-energy, low-protein formulas (HE-LPFs) are a safe and effective option as meal replacements for pre-dialysis chronic kidney disease (CKD) patients following a low-protein diet (LPD), according to a study.

In a recent randomized controlled trial, participants were divided into two groups: one receiving a once-daily HE-LPF and the other consuming normal food as part of a control group, both while maintaining an LPD. The study included 73 patients who completed the trial, and the intention-to-treat population was analyzed.

Results from 3-day food records indicated a significant decrease in the percentage of energy derived from protein (P < 0.05) and a simultaneous increase in the percentage of energy derived from fat (P < 0.05) in the HE-LPF group compared to the control group. However, there were no significant differences between the groups in terms of body weight, body composition, grip strength, renal function, electrolyte levels, or metabolic markers.

The HE-LPF group exhibited a high adherence rate, with 94.9% compliance at the end of the 4-week period. No adverse effects were observed, suggesting that HE-LPFs are safe to use as meal replacements for pre-dialysis CKD patients adhering to an LPD.

Reference
Yang WC, Hsieh HM, Chen JP, et al. Efficacy and Safety of a High-Energy, Low-Protein Formula Replacement Meal for Pre-Dialysis Chronic Kidney Disease Patients: A Randomized Controlled Trial. Nutrients. 2023;15(21):4506. doi: 10.3390/nu15214506. PMID: 37960159.

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