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Nonalcoholic Steatohepatitis (NASH)

Gender-specific bile acid profiles unveiled in liver diseases study

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A recent study has identified gender-specific bile acid profiles in non-alcoholic fatty liver disease (NAFLD) and distinct bile acid patterns in alcohol-associated liver disease (ALD).

The research, utilizing targeted mass spectrometry, found that women with NAFLD exhibited more severe cholestasis, while men seemed to better compensate for fat storage-driven bile acid dynamics, suggesting potential metabolic benefits.

The study also highlighted correlations between bile acid levels and enhanced liver fibrosis scores, emphasizing the potential clinical relevance of these findings.

Reference
Fitzinger J, Rodriguez-Blanco G, Herrmann M, et al. Gender-Specific Bile Acid Profiles in Non-Alcoholic Fatty Liver Disease. Nutrients. 2024;16(2):250. doi: 10.3390/nu16020250. PMID: 38257143.

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