Study highlights critical determinants of kidney failure in primary hyperoxaluria type 1

In primary hyperoxaluria type 1 (PH1) certain factors strongly affect the chances of kidney failure, including specific gene types and nephrocalcinosis, according to a study.

Some gene types, like c.508G>A (p.Gly170Arg), offer better chances of a favorable outcome whild, certain gene combinations, referred to as “null” homozygotes, significantly increase the risk of kidney failure, especially if unresponsive to vitamin B6.

Another vital finding was the impact of nephrocalcinosis, a condition characterized by calcium buildup in the kidneys. It was found to substantially elevate the risk of kidney failure.

In addition, the study highlighted the importance of monitoring levels of oxalate in the urine. Elevated oxalate levels were associated with a higher likelihood of kidney failure. However, it’s worth noting that oxalate levels can vary within an individual, which is an important factor to consider.

Overall, this research provides critical insights into PH1, offering a clearer understanding of factors influencing kidney outcomes.

Reference
Metry EL, Garrelfs SF, Deesker LJ, et al. Determinants of Kidney Failure in Primary Hyperoxaluria Type 1: Findings of the European Hyperoxaluria Consortium. Kidney Int Rep. 2023 Aug 4;8(10):2029-2042. doi: 10.1016/j.ekir.2023.07.025. PMID: 37849991; PMCID: PMC10577369.