3.90.33.254
dgid:
enl:
npi:0
-Advertisement-
-Advertisement-
Journal Scan
Neurology

Study Further Supports Role of Plasma Exchange in Stiff Person Syndrome

Posted on

Therapeutic plasma exchange (TPE) may be a beneficial treatment for acute exacerbations and long-term maintenance in patients with stiff person syndrome (SPS), according to a retrospective, single-institution study by Texas researchers that adds to the evidence supporting this modality for SPS. The investigators analyzed the clinical data and outcomes of 10 patients with anti-GAD65 positive SPS in which TPE was used to improve symptoms refractory to conventional treatment during an 8-year period. A review of patient records revealed the following:
– Six patients received chronic treatment with TPE following an initial course, with frequency of TPE guided by patients’ clinical response.

  • 2 patients had transient improvements with further disease progression;
  • 4 patients developed a relapse of symptoms when the interval between procedures was increased, with 1 experiencing worsening of symptoms following complete cessation of TPE due to lack of insurance coverage.

– Four patients underwent an acute hospitalized course of treatment with TPE.

  • 1 patient had complete resolution of symptoms;
  • 1 patient demonstrated a partial response;
  • 2 patients had no improvement.

Read more here.

Reference

Albahra S, Yates SG, Joseph D, et al. Role of plasma exchange in stiff person syndrome. Transfus Apher Sci. 2019;58(3):310-312. doi: 10.1016/j.transci.2019.03.015.

-Advertisement-
Related Articles
Potential Therapy for Rare Neurologic Disease
Apr 06, 2020
US FDA Grants Orphan Drug Designation for Retrotope’s RT001 in the Treatment of Progressive SupraNuclear Palsy (PSP)
Mar 16, 2020
TG Therapeutics Announces Data Presentations at the Upcoming American Academy of Neurology 72nd Annual Meeting
Mar 11, 2020
-Advertisement-
-Advertisement-
-Advertisement-
-Advertisement-
-Advertisement-