High-dose Corticosteroids Improves Odds of Recovery From Bell’s Palsy at 6 Months
Use of high-dose corticosteroids (prednisolone [PSL], ≥100 mg daily) reduces nonrecovery at 6 months in patients with Bell’s palsy compared with use of standard-dose corticosteroids (initial PSL, 50-60 mg), according to a systematic review and meta-analysis that included 8 studies. In the studies, patients on high-dose corticosteroids received doses ranging from 120 mg to 200 mg PSL daily. Compared with standard-dose corticosteroids, high-dose corticosteroids were associated with a significantly decreased nonrecovery at 6 months after the onset of Bell’s palsy (odds ratio 0.42; 95% confidence interval, 0.22-0.80). Based on the findings, the study investigators concluded that “further prospective study is needed to identify an adequate dose of corticosteroids in these patients.”
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Fujiwara T, Namekawa M, Kuriyama A, Tamaki H. High-dose corticosteroids for adult Bell’s palsy: systematic review and meta-analysis. Otol Neurotol. 2019 Jul 8. doi: 10.1097/MAO.0000000000002317.