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Lurbinectedin Shows Promise in Small Cell Lung Cancer

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Small-cell lung cancer (SCLC) accounts for approximately 15% of lung cancer cases and is almost always fatal. The US Food and Drug Administration recently granted Orphan Drug status to lurbinectedin (PM1183), a second-generational investigational inhibitor of RNA polymerase II, an enzyme critical to transcription and DNA repair. The decision was based on preliminary findings from a multicenter, multinational phase 2 trial that included 50 evaluable patients with advanced SCLC. Patients received a 1-hour infusion of lurbinectedin 3.2 mg/m2 every 3 weeks. After a median of 5 cycles, 38% of patients had a partial response and 40% had stable disease. Median progression-free survival was 4.2 months, and mediation duration of response was 5.3 months. The most common adverse event was myelosuppression.

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Perez JMT, Leary A, Besse B, et al. Efficacy and safety of lurbinectedin (PM1183) in small cell lung cancer (SCLC): results from a phase 2 study. Presented at: 2018 American Society of Clinical Oncology; June 1-5, 2018; Chicago, Illinois. Abstract 8570.

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