Thyroid Eye Disease

Corneal changes may help identify thyroid eye disease earlier

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Thyroid eye disease (TED)-related corneal changes may help diagnose TED, especially “silent” TED, earlier, according to a study.

This retrospective cross-sectional study included 52 eyes of 26 patients with TED and 40 eyes of 20 controls. All participants underwent a corneal topography examination using a Galilei dual Scheimpflug camera.

The following parameters were significantly different (P ≤ 0.05). between the group of patients with TED and the controls:

-Inferior-Superior Index
-Keratoconus Prediction Index
-Surface Asymmetry Index
-Surface Regularity Index
-Simulated keratometry astigmatism
-Anterior instantaneous astigmatism axis

In addition, patients in the TED group had a more oblique anterior instantaneous astigmatism axis and a more scattered distribution in the anterior instantaneous astigmatism axis compared to the control group. There was no significant difference in corneal topographic parameters among the different thyroid dysfunction groups.

Chang YM, Weng TH, Tai MC, et al. Corneal topographic changes in patients with thyroid eye disease: A retrospective cross-sectional study. Cont Lens Anterior Eye. 2023;101843. doi: 10.1016/j.clae.2023.101843. Epub ahead of print. PMID: 37037712.