Cryotherapy, topical imiquimod combination may be effective in cutaneous Kaposi sarcoma

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Treatment with a combination of cryotherapy and topical imiquimod appears to be effective in patients with cutaneous Kaposi sarcoma, and compared to other treatment modalities, relatively low risk, according to a study.

In this study, researchers included data from 9 patients with cutaneous Kaposi sarcoma who received combination therapy of cryotherapy followed by topical imiquimod 3 times a week for 2 months.

During a median duration of follow-up of 58 weeks, 93% of lesions and 89% f patients experienced complete resolution.

Reported side effects included pain during cryotherapy, occasional blister formation after cryotherapy, and mild inflammation due to imiquimod.

No infections were noted.

Gu L, Lin E, Liu S, et al. Efficacy of Immunotherapy with Combination of Cryotherapy and Topical Imiquimod for Treatment of Kaposi Sarcoma. J Med Virol. 2022;doi: 10.1002/jmv.28396. Epub ahead of print. PMID: 36504005.