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Hematology

Inherited bleeding disorders significantly increase the risk of postpartum hemorrhage

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Women with inherited bleeding disorders (IBDs) have a higher risk of postpartum hemorrhage (PPH), according to a study that stressed the importance of assessing individual risk factors for optimal maternal outcomes during delivery.

The relationship between IBD and maternal bleeding in the presence of other risk factors such as anemia needs further study, and the underlying pathways connecting IBD and PPH are not well understood.

This retrospective cohort study included 29,661 (out of 601,773) women who experienced PPH after an in-hospital, live, or stillborn delivery.

IBD was found to be an independent risk factor for PPH among the total cohort and primiparous women. Experiencing PPH before was associated with an increased risk of PPH in multiparous women, although there was no association with IBD.

Among all cohorts, predelivery anemia, placental conditions, multifetal gestation, and induction of labor were associated with increased PPH risk.

Reference
Hews-Girard JC, Galica J, Goldie C, et al. Identifying the effect of inherited bleeding disorders on the development of postpartum hemorrhage: a population-based, retrospective cohort study. Res Pract Thromb Haemost. 2023;7(2):100104. doi: 10.1016/j.rpth.2023.100104. PMID: 37063757; PMCID: PMC10099304.

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