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Elevated Risk for Cause-Specific Mortality in Waldenström Macroglobulinemia

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Patients with Waldenström macroglobulinemia (WM) have elevated non-cancer mortality risks, according to a study published in the British Journal of Haematology.

In the study, researchers identified the cause of death for 3108 patients with lymphoplasmacytic lymphoma (LPL) and 4181 patients with WM (N = 7289).

The 16-year cumulative mortality was 23.2% and 33.4% for lymphomas, 8.4% and 11.2% for nonlymphoma cancers, and 14.7% and 48.7% for noncancer causes in patients <65 years and >75 years at the time of diagnosis, respectively.

There was 20% higher risk for death due to noncancer causes compared with the general population in patients with WM.


Dalal NH, Dores GM, Curtis RE, Linet MS, Morton LM. Cause-specific mortality in individuals with lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia, 2000-2016 [published online ahead of print, 2020 Feb 23]. Br J Haematol. 2020;10.1111/bjh.16492. doi:10.1111/bjh.16492