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Autoimmune
Journal Scan

Belimumab plus standard therapy better than standard therapy alone for lupus nephritis

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Belimumab plus standard therapy is superior to standard therapy alone in patients with lupus nephritis, according to results of a 2-year randomized controlled trial published in New England Journal of Medicine.

In this phase 3 trial, adults with active lupus nephritis were assigned to receive either intravenous belimumab (n = 224) or placebo (n = 224) in addition to standard therapy. The primary end point was a primary efficacy renal response at week 104. Secondary endpoints included a complete renal response.

Significantly more patients in the belimumab group had a primary efficacy renal response and a complete renal response at week 104 compared to those in the placebo group (43% vs. 32% and 30% vs. 20%, respectively).

Patients in the belimumab group were at a lower risk of a renal-related event or death than those in the placebo group.

Reference
Furie R, Rovin BH, Houssiau F, et al. Two-year, randomized, controlled trial of belimumab in lupus nephritis. N Engl J Med. 2020; 383:1117-1128. DOI: 10.1056/NEJMoa2001180

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