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Cholic acid intervention demonstrates safe and well-tolerated rise in cholesterol for SLOS

Patients with Smith-Lemli-Opitz syndrome (SLOS) with low plasma cholesterol levels treated with cholic acid supplementation experienced a significant increase in plasma cholesterol levels after 2 months, according to a pilot study. The standard therapy for SLOS often involves dietary cholesterol supplementation. However, due to impaired bile acid synthesis, the absorption...

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