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Oncology
Sarcoma

What impact does the amount of chemotherapy-induced necrosis have on outcomes in Ewing sarcoma?

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A recent study examined the impact that the amount of chemotherapy-induced necrosis has on overall survival, local recurrence-free survival, metastasis-free survival, and event-free survival in patients with Ewing sarcoma.

Researchers found that in patients with Ewing sarcoma, complete tumor necrosis after neoadjuvant chemotherapy should be used as a parameter to grade response to treatment as satisfactory.

“Any viable tumor in these patients after neoadjuvant treatment should be of oncologic concern,” the authors wrote.

The study analyzed data from 427 patients who had Ewing sarcoma or tumors in the Ewing sarcoma family treated with preoperative chemotherapy and surgery.

Compared with patients who had a partial response to chemotherapy, patients with a complete tumor response increases in:
-Overall survival
-Recurrence-free survival
-Metastasis-free survival
-Event-free survival.

Reference
Lozano-Calderón SA, Albergo JI, Groot OQ, et al. Complete tumor necrosis after neoadjuvant chemotherapy defines good responders in patients with Ewing sarcoma. Cancer. 2022;doi: 10.1002/cncr.34506. Epub ahead of print. PMID: 36305090.

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