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Ultrasound-guided core needle biopsy not inferior to incisional biopsy in sarcoma

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Ultrasound-guided core needle biopsy (CNB) is highly accurate at diagnosing and determining histologic subtype in patients with suspected soft tissue sarcomas (STS), according to a study.

According to the study authors, CNB offers advantages over incisional biopsy (IB) when it comes to patient morbidity, time, and cost. This study was undertaken to determine which technique, if any, provides more accurate diagnosis of STS.

Biopsy technique prior to surgery was used to classify 2 groups of patients with STS. Overall, 153 patients were included, with 95 undergoing CNB and 58 undergoing IB.

In the CNB and IB groups, malignancy was correctly diagnosed in 87% and 93% of cases, respectively. Histologic subtype was correctly identified in 80% and 83%, respectively.

No significant differences in the correct diagnosis rates were found between the techniques.

Three patients who had IB experienced complications with 2 developing pulmonary embolism and 1 developing a surgical site infection.

Cernakova M, Hobusch GM, Amann G, et al. Diagnostic accuracy of ultrasound-guided core needle biopsy versus incisional biopsy in soft tissue sarcoma: an institutional experience. Sci Rep. 2021;11(1):17832. doi: 10.1038/s41598-021-96953-w. PMID: 34497298; PMCID: PMC8426501.