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Journal Scan
Sarcoma

Real-world study confirms efficacy of anlotinib in soft tissue sarcoma

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After the ALTER0203 clinical trial demonstrated the antitumor effects of anlotinib on advanced soft tissue sarcoma (STS) after the failure of standard chemotherapy, researchers sought to confirm the efficacy in a real-world setting.  

 

Data from 209 patients with unresectable locally advanced or metastatic STS who received ≥1 dose of anlotinib were retrospectively analyzed. The median age was 48 (range 11-85) years. Patients were followed for a median of 18.7 months. The median progression-free survival and overall survival were 6.1 months [95% confidence interval (CI): 4.9-7.2], and 16.4 months (95% CI: 13.6-19.1), respectively. The objective response rate was 13.4%.

The following were significantly associated with progression-free survival:

-Nutritional status

-Eastern Cooperative Oncology Group (ECOG) performance status

-Anlotinib treatment patterns (combination therapy or switch maintenance therapy vs. monotherapy)


The following were
predictive of overall survival:
-Pathological grade
-Nutritional status
-ECOG performance status
-anlotinib treatment patterns

A dose reduction was needed in 14.8% of patients and treatment discontinuation in 12% of patients due to anlotinib-related toxicity.

Referene

Zhang RS, Liu J, Deng YT, et al. The real-world clinical outcomes and treatment patterns of patients with unresectable locally advanced or metastatic soft tissue sarcoma treated with anlotinib in the post-ALTER0203 trial era. Cancer Med. 2022;doi: 10.1002/cam4.4613. Epub ahead of print. PMID: 35191609.

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