Journal Scan

How does treatment at a high-volume institution impact overall survival in STS?

Posted on May 27, 2021

No significant association between socioeconomic factors and overall survival (OS) was found in patients with soft tissue sarcoma (STS) treated at a high-volume institution, according to a retrospective analysis at a single institution.

Of the 435 patients included, 37% had grade 3 tumors, 44% had disease >5 cm, and 38% were privately insured. More than half (52%) of patients received neoadjuvant therapy prior to resection.
According to the study, “median distance from the treatment center was 42 miles and median area deprivation index (ADI) was 5 (10 representing most deprived communities).”
Multivariate analysis found that higher tumor grade, tumor size >5 cm, and involved lymph nodes were significantly associated with OS.

The following factors were not found to be associated with OS:
Age at diagnosis
Marital status
Employment status
Urban vs. rural location
Distance to the treatment center

“Treatment at a high-volume institution may mitigate the importance of socio-economic factors in the OS of STS,” the authors concluded.

Eastman BM, Hippe DS, Wootton LS, et al. Socio-economic factors do not affect overall survival in soft tissue sarcoma when patients treated at a single high-volume center. BMC Cancer. 2021;21(1):620. doi: 10.1186/s12885-021-08352-z. PMID: 34039294.