Diabetes mellitus linked to worse clinical outcome in patients with soft tissue sarcoma

Diabetes was associated with negative clinical outcomes of patients with soft tissue sarcoma after curative resection, according to a study.

In this retrospective study of 475 patients with soft tissue sarcoma who underwent curative resection, diabetes mellitus was significantly associated with adverse cancer specific survival (sub-hazard ratio: 2.14, 95% CI 1.18-3.90, P = 0.013 ) and overall survival (HR): 2.05, 95% CI 1.28-3.28), which remained significant after adjusting for established prognostic factors.

Diabetes mellitus was not associate with disease-free survival and mean pre-surgery glucose levels were not significantly associated with worse outcomes.

Reference
Stelzl A, Aziz F, Riedl JM, et al. Diabetes mellitus is independently associated with adverse clinical outcome in soft tissue sarcoma patients. Sci Rep. 2020;10(1):12438. Published 2020 Jul 24. doi:10.1038/s41598-020-69237-y