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Sarcoma

Carbon ion radiotherapy shows potential in some bone sarcomas

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Carbon ion radiotherapy is safe and effective for bone sarcomas and may improve local control, overall survival, and lower acute and late toxicity, according to a study.

In this meta-analysis, researchers identified 12 studies including 897 patients with bone sarcomas (chordoma, n = 526; chondrosarcoma, n = 255; osteosarcoma, n = 112; and other sarcomas, n = 4).

The local control rate at 1 year was 98.5%, at 2 years was 85.8%, at 3 years was 86%, at 4 years was 91.1%, at 5 years was 74.3%, and at 10 years was 64.7%. The overall survival rate were 99.9%, 89.6%, 85%, 92.4%, 72.7%, and 72.1%, respectively.

Overall, the incidence of acute and late toxicities was mostly grade 1 to grade 2, and grade 1 to grade 3, respectively.

Reference

Dong M, Liu R, Zhang Q, et al. Efficacy and safety of carbon ion radiotherapy for bone sarcomas: a systematic review and meta-analysis. Radiat Oncol. 2022;17(1):172. doi: 10.1186/s13014-022-02089-0. PMID: 36284346.

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