Anlotinib therapy for advanced sarcomas has more acceptable side than some alternatives

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Anlotinib monotherapy or used in combination may be more effective in certain advanced cancer and have more acceptable side effects, according to a study.

In this retrospective analysis, 22 patients with advanced sarcomas with measurable target lesions who had taken anlotinib regularly for >12 months were included.

Primary diseases included alveolar soft part sarcoma, synovial sarcoma, leiomyosarcoma, and others, with metastasis sites in the lungs in 15 cases, lymph nodes in 4 cases, and multiple sites in 3 cases. Chemotherapy had been administered previously in 14 patients.

The current therapy protocol was oral anlotinib alone for 9 cases, combination chemotherapy for 9 cases, and combination immunotherapy (anti-PD-1) for 4 cases.

The highest clinical efficacy was complete remission (CR) in 18.18% of cases (n = 4), partial response (PR) in 22.73% of cases (n = 5), and stable disease in 59.09% of cases (n = 13), with an odds ratio of response of 40.91%.

The mean PFS for the CR group was 16.50 months, 14.50 months for PR group, and 29.31 months in the stable disease group.

Hand-foot syndrome, hypertension, and leukopenia were the main adverse effects noted.


Yao W, Du X, Wang J, et al. Long-Term Efficacy and Safety of Anlotinib as a Monotherapy and Combined Therapy for Advanced Sarcoma. Onco Targets Ther. 2022 Jun 14;15:669-679. doi: 10.2147/OTT.S365506. PMID: 35726279; PMCID: PMC9206457.