Study highlights risk factors of vena cava syndrome in Behçet’s syndrome

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Potential risk factors of vena cava syndrome (VCS) in patients with Behçet’s syndrome (BS) include male, early-onset Behçet’s syndrome (BS), ESR >60 mm/hour, and pathergy reaction, according to a study.

In this case-control study data from 55 cases of patients with BS with VCS and 2 patients without VCS for each VCS case using risk-set-sampling was used to detect the risk factors of VCS and overall outcomes.

Male gender (OR 11.16, 95%CI 3.34-37.32), early-onset BS (<18 years) (OR 5.57, 95%CI 1.58-19.69), ESR >60 mm/hr (OR 3.83, 95%CI 1.02-12.23), and pathergy reaction (OR 5.10, 95%CI 2.11-12.32) were identified potential risk factors of VCS in BS patients with a multivariable logistic regression analysis.

Spectral computed tomography imaging was found to be valuable in detecting thrombosis in BS patients with inferior VCS.

Over a median 3.3 years follow-up, the estimated 1- and 5-year survival rates were 96.3% and 94.2%, respectively, and the estimated 1- and 5-year relapse-free rates were 93.9% and 78.0%, respectively.

Zhou J, Zhang D, Wang Z, et al. The clinical features, image findings and risk factors of vena cava syndrome in Behçet’s syndrome. Clin Exp Rheumatol. 2022;doi: 10.55563/clinexprheumatol/r6her6. Epub ahead of print. PMID: 35819814.