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Metronomic Cyclophosphamide Shows Long-Lasting Benefit in Chordoma Patient

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Chordomas are rare cancerous tumors that affect the spine and can occur anywhere from the base of the skull to the tailbone. Because of how rare these tumors are, systemic treatments have not been well studied. Systemic treatments often include platinum-based chemotherapy in combination with small-molecule tyrosine kinase inhibitors, such as imatinib, lenvatinib, or sorafenib. Once these treatments fail, however, it is unclear how to proceed. A case report described long-lasting clinical and radiological benefit with metronomic cyclophosphamide in a patient who experience uncontrolled pain after experiencing disease progression on cisplatin and imatinib.

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Spalato Ceruso M, Napolitano A, Silletta M, Vincenzi B. Unexpected benefit from an ‘old’ metronomic chemotherapy regimen in advanced chordoma. BMJ Case Rep. 2019;12(6). pii: e228728. doi: 10.1136/bcr-2018-228728.

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