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Oncology

Stopping checkpoint inhibitors after remission OK in some metastatic melanomas

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Most complete remissions remained durable after elective discontinuation of checkpoint inhibitor treatment in patients with metastatic melanomas, potentially decreasing the impact of drug toxicities and financial burden, according to a study.

This retrospective review included 132 checkpoint inhibitor-treated patients, 46 patients who underwent elective treatment discontinuation after 2 negative scans 3 months apart.

At 1 year and 3 years following treatment discontinuation, the progression-free survival was 97.5% and 94.7%, respectively. There was a median duration of follow-up of 26 months. Overall, 8.7% (4 out of 46) of those that discontinued treatment relapsed with a median time to relapse of 27 months.

Of the entire cohort, median disease-specific survival was not reached and was 100% at 4 years from the start of therapy.

There were 2 patient deaths, 1 from melanoma and 1 from an unrelated illness.

Reference
Perez L, Samlowski W, Lopez-Flores R. Outcome of Elective Checkpoint Inhibitor Discontinuation in Patients with Metastatic Melanoma Who Achieved a Complete Remission: Real-World Data. Biomedicines. 2022;10(5):1144. doi: 10.3390/biomedicines10051144. PMID: 35625881.

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