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BRAF mutation is a risk factor for disease recurrence after surgery in metastatic melanoma

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The presence of the BRAF mutation was statistically significant for disease recurrence after surgery amongst patients with advanced malignant melanoma, according to a study.

In this retrospective study, data from 52 patients treated with immunotherapy and BRAF/MEK inhibitors for disseminated malignant melanoma were analyzed to determine risk factors and treatment results over a median follow-up of 31 months.

The median progression-free survival (PFS) 1 was 6 months (1-44 months). In 27 patients (52%), a second-line systemic treatment was administered. The median PFS2 was 2 months (0-27 months), and the median overall survival (OS) was 31 months (6-108 months).

Having a BRAF mutation was a statistically significant risk factor for disease recurrence after surgery.

The median PFS1 was 7 months in patients undergoing anti-BRAF/MEK therapy and 4 months in patients undergoing mono-immunotherapy.

Amongst those treated with BRAF inhibitors, the 12-month PFS1 rate was 29% and the 24-month PFS1 rate was 7%. For patients treated with mono-immunotherapy, the 12- and 24-month PFS1 rates were 13 and 0%, respectively. The type of treatment used had no effect on OS.

Szatkowska L, Sieczek J, Tekiela K, et al. Outcomes of Patients with Metastatic Melanoma-A Single-Institution Retrospective Analysis. Cancers (Basel). 2022;14(7):1672. doi: 10.3390/cancers14071672. PMID: 35406444; PMCID: PMC8997072.