Journal Scan

Study Identifies Cortically Driven Process in Lennox-Gastaut Syndrome

Posted on

A study assessing brain regions underlying interictal generalized paroxysmal fast activity (GPFA) found reproducible evidence of a cortically driven process within the epileptic network of Lennox-Gastaut syndrome (LGS). The study included 10 children and 15 adults who underwent concurrent scalp EEG-fMRI with and without anesthesia, respectively, during which a total of 1045 GPFA events were identified (cumulative duration, 1433 seconds). Assessment of these events revealed the following:

  • Activation occurred in distributed association cortical areas, thalamus, and brainstem (P <.05, corrected for family-wise error).
  • Activation was similar across individual patients, particularly in the frontoparietal cortex, regardless of the etiology of their epilepsy (ie, structural, genetic, unknown).
  • Dynamic casual modeling indicated GPFA was most likely driven by the prefrontal cortex, with propagation occurring first to the brainstem and then from the brainstem to the thalamus.

Read more here.


Warren AEL, Harvey AS, Vogrin SJ, et al. The epileptic network of Lennox-Gastaut syndrome: cortically driven and reproducible across age. Neurology. 2019 Jun 21. pii: 10.1212/WNL.0000000000007775. doi: 10.1212/WNL.0000000000007775.

Related Articles
Potential Therapy for Rare Neurologic Disease
Apr 06, 2020
US FDA Grants Orphan Drug Designation for Retrotope’s RT001 in the Treatment of Progressive SupraNuclear Palsy (PSP)
Mar 16, 2020
TG Therapeutics Announces Data Presentations at the Upcoming American Academy of Neurology 72nd Annual Meeting
Mar 11, 2020