Tacrolimus plus glucocorticoids regimen effective in lupus nephritis
Tacrolimus combined with glucocorticoids in patients with lupus nephritis (LN) is an effective regimen that may result in fewer adverse reactions, such as reduced inflammatory factors, according to a study.
A total of 80 patients with lupus nephritis were randomly divided into an experimental group (n = 40) where they were treated with tacrolimus combined with glucocorticoid or a control group (n = 40) where they were treated with cyclophosphamide combined with glucocorticoids for 1 year.
The total efficacy of the experimental group and the control group was 92.5% and 75%, respectively, and the incidence of adverse reactions was 20% and 42.5%, respectively.
The levels of CRP, IL-6, and other inflammatory factors were lower and indicators such as 24-hour urine protein quantification, serum albumin, blood creatinine, and urea nitrogen were improved after treatment in the experimental group compared to the control group.
ESR, anti-DSDNA antibody positive rate, and SLEDAI score were decreased in the experimental group, and complement C3 and C4 levels were increased.
Li L, Du Y, Ji J, et al. Analysis of the safety and efficacy of tacrolimus combined with glucocorticoid in the treatment of lupus nephritis. Pak J Med Sci. 2022;38(5):1285-1291. doi: 10.12669/pjms.38.5.5117. PMID: 35799716; PMCID: PMC9247779.