Lupus low disease activity state possible target in children with lupus nephritis
It is possible to achieve lupus low disease activity state (LLDAS) in children with lupus nephritis, which is associated with lower rates of kidney flare and damage, according to a study.
There were more frequent presence of autoimmune hemolytic anemia, anti-Sm and anti-dsDNA antibodies, proliferative lupus nephritis, and hypertension at onset among children with lupus nephritis who did not achieve LLDAS after the first 6 months of treatment.
Patients who did not achieve LLDAS-50 (LLDAS at least 50% of the observation time), had a lower rate of complete kidney response and a higher rate of hypertension. Lower rates of kidney flare and damage accrual were associated with attaining both LLDAS after initial treatment and LLDAS-50.
Kisaoglu H, Baba O, Kalyoncu M. Lupus low disease activity state as a treatment target for pediatric patients with lupus nephritis. Pediatr Nephrol. 2022;doi: 10.1007/s00467-022-05742-8. Epub ahead of print. PMID: 36156735.