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Lupus Nephritis

Lupus low disease activity state possible target in children with lupus nephritis

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It is possible to achieve lupus low disease activity state (LLDAS) in children with lupus nephritis, which is associated with lower rates of kidney flare and damage, according to a study.

There were more frequent presence of autoimmune hemolytic anemia, anti-Sm and anti-dsDNA antibodies, proliferative lupus nephritis, and hypertension at onset among children with lupus nephritis who did not achieve LLDAS after the first 6 months of treatment.

Patients who did not achieve LLDAS-50 (LLDAS at least 50% of the observation time), had a lower rate of complete kidney response and a higher rate of hypertension. Lower rates of kidney flare and damage accrual were associated with attaining both LLDAS after initial treatment and LLDAS-50.

Reference
Kisaoglu H, Baba O, Kalyoncu M. Lupus low disease activity state as a treatment target for pediatric patients with lupus nephritis. Pediatr Nephrol. 2022;doi: 10.1007/s00467-022-05742-8. Epub ahead of print. PMID: 36156735.

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