Early proteinuria levels predict complete renal response in lupus nephritis
Several factors taken at baseline and 3 months after starting induction treatment can predict complete renal response (CRR) and renal flares once CRR is achieved, according to a study.
In this retrospective cohort study, 104 patients with proliferative LN (class III/IV) were followed for 36 months. CRR was defined as s proteinuria <0.5g/day with normal renal function and renal flare was defined as proteinuria >1g/day after CRR attainment.
In total, 91.7% of participants reached CRR, within a median time of 6 months. Independent predictors of CRR included Proteinuria <2g/day at baseline and 3 months after the start of induction therapy. Of the patients who reached CCR, 18.4% had renal flares after a mean time of 16.5±8.6 months. Independent predictors of renal flares included age ≤25 at LN diagnosis and positive anti-RNP.
Luís MSF, Bultink IEM, da Silva JAP, et al. Early predictors of renal outcome in patients with proliferative lupus nephritis: a 36-months cohort study. Rheumatology (Oxford). 2021;keab126. doi: 10.1093/rheumatology/keab126. Epub ahead of print. PMID: 33560332.