Complete response definition impacts clinical judgment in lupus nephritis
Different complete remission criteria in children with proliferative lupus nephritis influences when remission is determined, according to a study.
In this study, data from 161 children with proliferative lupus nephritis underwent induction therapy of mycophenolate mofetil (MMF; n = 27) or cyclophosphamide (CYC; n = 134). Different criteria dramatically influenced complete remission rates, with CR rates in the MMF group ranging from 18.5% to 74.1% and rates in the CYC group ranging from 16.4% to 73.9%.
The authors also noted that “comparison between the 2 drugs in induction treatment under different criteria showed an opposite trend in efficacy.” Urinary protein and urinary red blood cells were factors that led to disagreement.
Chen L, Tan M, Huang J, et al. Effects of alternative remission criteria on outcome of pediatric proliferative lupus nephritis: a multi-center retrospective study of pediatric proliferative lupus nephritis. Am J Transl Res. 2021;13(5):4510-4520. PMID: 34150031; PMCID: PMC8205752.