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Lupus Nephritis

Mycophenolate mofetil plus tacrolimus most effective induction treatment for LN

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Mycophenolate mofetil (MMF) in combination with tacrolimus was found to be the most effective induction treatment for patients with lupus nephritis (LN), according to a network meta-analysis of randomized controlled trials.

The analysis compared the following as induction therapy for patients with lN:

-Voclosporin + MMF

-Tacrolimus + MMF

-Monotherapy with MMF or cyclophosphamide

A total of 4 randomized controlled trials including 936 patients in total were included. Tacrolimus + MMF and voclosporin + MMF were found to be more effective than monotherapy, whereas tacrolimus + MMF was found to be more effective than voclosporin + MMF.

The study found that based on severe event rates, monotherapy was the safest treatment followed by voclosporin + MMF and tacrolimus + MMF.

Lee YH, Song GG. A network meta-analysis of randomized controlled trials comparing the effectiveness and safety of voclosporin or tacrolimus plus mycophenolate mofetil as induction treatment for lupus nephritis. Z Rheumatol. 2021;doi: 10.1007/s00393-021-01087-z. Epub ahead of print. PMID: 34545430.