Race linked to short-term outcomes in childhood-onset lupus nephritis

Approximately one-third of individuals with childhood-onset systemic lupus erythematosus (cSLE) develop lupus nephritis (LN), according to new data from a real-world cohort.

Of the 677 patients with cSLE from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) prospective registry, 32% had documented LN. Of those diagnosed with LN during the study period, 93% were diagnosed <2 years from their lupus diagnosis.

Researchers also found that kidney function decline was more common in Black children with cSLE than non-Black children and that worse short-term renal outcomes were associated with Black race.

In this cohort of patients, end-stage kidney disease was rare.

Reference
Vazzana KM, Daga A, Goilav B, et al; CARRA Registry investigators. Principles of pediatric lupus nephritis in a prospective contemporary multi-center cohort. Lupus. 2021;:9612033211028658. doi: 10.1177/09612033211028658. Epub ahead of print. PMID: 34219529