Patients with axial tumors more like to have local recurrence after surgery

Patients with axial tumors may be at an increased risk of local recurrence (LR) while patients with poor histological response may be at an increased risk for new metastatic disease (NM), according to a study.

This open-label, international, phase 3 randomized controlled trial, included a subset of 1631 metastases-free patients from 1965 patients with high-grade resectable osteosarcoma included in the European and American Osteosarcoma Study.

An intermediate event occurred in 526 patients and 305 patients died during the study period.

Patients with an axial tumor were more at risk of LR after surgery (HR=10.84, 95% CI 8.46 to 13.86) and death after LR (HR=11.54, 95% CI 6.11 to 21.8). Patients with poor histological response had an increased risk of NM (HR=5.81, 95% CI 5.31 to 6.36); 3 years post-surgery however, the risk sharply decline.

Patients <12 years of age had a lower intermediate event risk compared with patients 12-18 years of age but an increased risk of subsequent death. Patients older than 18 years of age had a decreased risk of death after event.

Reference
Hazewinkel AD, Lancia C, Anninga J, et al. Disease progression in osteosarcoma: a multistate model for the EURAMOS-1 (European and American Osteosarcoma Study) randomised clinical trial. BMJ Open. 2022;12(3):e053083. doi: 10.1136/bmjopen-2021-053083. PMID: 35246418.