Gout not linked with increased cardiovascular events in people with PAD

Gout was not independently associated with increased cardiovascular events in people with peripheral artery disease (PAD), according to a study in Atherosclerosis.

In this prospective study, 4308 people with PAD, including carotid artery disease, aortic or peripheral aneurysm, and lower limb PAD, were included and followed for a median of 2.1 years. Of the participants, 334 had a history of gout.

Participants who had gout were at increased risk of myocardial infarction, stroke or cardiovascular death and all-cause mortality but the associations were lost after Kaplan-Meier survival analysis and Cox-proportional hazard analysis. In the propensity-score matched cohort, gout was not significantly associated with an increased risk for MACE or all-cause mortality.

Reference
Singh TP, Wong S, Quigley F, Jenkins J, Golledge J. Association of gout with major adverse cardiovascular events and all-cause mortality in patients with peripheral artery disease [published online ahead of print, 2020 Sep 8]. Atherosclerosis. 2020;312:23-27. doi:10.1016/j.atherosclerosis.2020.08.029