Atezolizumab Plus Bevacizumab Improves Overall Survival in Unresectable HCC Compared with Sorafenib
Atezolizumab combined with bevacizumab improves overall and progression-free survival outcomes compared with sorafenib in patients with unresectable hepatocellular carcinoma, according to an article in New England Journal of Medicine.
The randomized phase 3 IMbrave150 study found that overall survival at 12 months in patients treated with the combination therapy was 67.2% compared with 54.6% in patients treated with sorafenib. Patients treated with atezolizumab–bevacizumab had a median progression-free survival of 6.8 months compared with 4.3 month in those treated with sorafenib.
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Finn RS, Qin S, Ikeda M, et al. Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma. N Engl J Med. 2020; 382:1894-1905. DOI: 10.1056/NEJMoa1915745