Interstitial Lung Disease
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Inhaled treprostinil improves exercise capacity in pulmonary hypertension due to ILD

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Patients with pulmonary hypertension due to interstitial lung disease (ILD) had improvements in exercise capacity from baseline when treated with inhaled treprostinil, according to a study.

A total of 326 patients with interstitial lung disease and pulmonary hypertension were randomized to receive inhaled treprostinil 4 times daily (n = 163) or placebo (n = 163). 

At week 16, patients in the treatment group had improvements from baseline in the 6-minute walk distance compared to those receiving placebo. N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels decreased 15% in patients treated with inhaled treprostinil compared with an increase of 46% with patients in the placebo group.

Clinical worsening occurred in 22.7% and 33.1% of patients in the treprostinil group and placebo group, respectively.

Adverse events were cough, headache, dyspnea, dizziness, nausea, fatigue, and diarrhea

Waxman A, Restrepo-Jaramillo R, Thenappan T, et al. Inhaled treprostinil in pulmonary hypertension due to interstitial lung disease. N Engl J Med. 2021; 384:325-334. DOI: 10.1056/NEJMoa2008470