How does anticancer drug type impact DILD?

Cytotoxic anticancer drugs were found to result in worse prognoses in drug-induced interstitial lung disease (DILD) compared to other pharmacological types, according to a study.

In this study, 47 patients with lung cancer who were treated with chemotherapy were grouped according to different pharmacological types of anticancer drugs. Eleven patients were in the kinase inhibitor (KI) group, 16 in the immune-checkpoint inhibitor (ICI) group, and 20 in the cytotoxic anticancer drug group.

The researchers found that after the DILD event, the 90-day mortality rate was significantly higher in patients in the cytotoxic anticancer drug group than those in the KI and ICI groups.

Reference
Iwashita K, Mizuno T, Kumazawa S, et al. Prognosis of patients with interstitial lung disease induced by different pharmacological types of anticancer drugs. Anticancer Res. 2021;41(5):2563-2568. doi: 10.21873/anticanres.15034. PMID: 33952484.