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Internal Medicine

Low-dose oral iron therapy effective for iron-deficient non-anemic women

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Low-dose oral iron therapy can effectively treat iron deficiency without anemia in premenopausal women, according to a study.

The study included 36 iron-deficient non-anemic premenopausal women with a serum ferritin level of ≤30 ng/ml and a hemoglobin level of ≥117 g/l. The participants, who had a normal body mass index (BMI) and no hypermenorrhea, were administered 6 mg of elemental oral iron (equivalent to 18.6 mg ferrous sulphate) twice daily for 8 weeks.

Over the 8-week period, both serum ferritin and hemoglobin levels significantly increased from 18 ng/ml to 33 ng/ml (P <0.001) and from 135 g/l to 138 g/l (P = 0.014), respectively. However, researchers noted that systolic blood pressure also increased from 114 mmHg to 120 mmHg (P = 0.003).

Additionally, participants reported an improvement in their self-reported health status after the 8-week treatment period.

Reference
Simic S, Karczewski M, Klapdor S, et al. Effectiveness of low-dose iron treatment in non-anaemic iron-deficient women: a prospective open-label single-arm trial. Swiss Med Wkly. 2023;153:40079. doi: 10.57187/smw.2023.40079. PMID: 37229775.

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