Study Finds Innate Protein That Restricts HIV Replication by Targeting Lipid Rafts

The human protein apolipoprotein A-I binding protein (AIBP) inhibits HIV replication by targeting lipid rafts and reducing virus-cell fusion, according to a new study published in the premier American Society for Microbiology journal mBio by researchers from the George Washington University. These results provide the first evidence suggesting that AIBP is an innate immunity factor that restricts HIV replication by modifying lipid rafts on cells targeted by HIV.

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Reference

Dubrovsky L, Ward A, Choi SH, et al. Inhibition of HIV replication by apolipoprotein A-I binding protein targeting the lipid rafts. mBio. 2020. DOI: 10.1128/mBio.02956-19