Study finds varying bone density trends in adult patients with growth hormone deficiency

Adults with growth hormone deficiency (AGHD) exhibit varying patterns of bone mineral density (BMD) changes based on the age at which the deficiency onset occurs, according to a new study.

Specifically, the study found that patients with childhood-onset AGHD initially have lower BMD levels compared to those with adult-onset AGHD. However, over time, childhood-onset patients experience greater annual increases in BMD compared to adult-onset patients.

Additionally, the study identified childhood onset, along with low serum testosterone and FT4 levels, as independent risk factors for BMD loss in AGHD patients.

These findings emphasize the importance of tailored treatment approaches to address the unique bone health needs of AGHD patients and underscore the significance of appropriate replacement therapy for long-term bone health in this population.

Reference
Yang H, Chen M, Xu H, et al. Bone mineral density in adults growth hormone deficiency with different ages of onset: a real-world retrospective study. Endocrine. 2024;doi: 10.1007/s12020-024-03786-4. Epub ahead of print. PMID: 38536548.