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Panhypopituitarism may not lead to worse pregnancy outcomes

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Women with panhypopituitarism have comparable pregnancy outcomes to the general population, according to a study.

Panhypopituitarism causes the pituitary gland to produce an inadequate or reduced amount of hormones.

In this retrospective population-based study, data from the deliveries of 120 women with panhypopituitarism during pregnancy and a control group of all other pregnant women from the Healthcare Cost and Utilization Project – Nationwide Inpatient Sample (n = 8,732,641) were analyzed.

No significant differences were found in the risk of the following:
-Developing gestational hypertension
-Gestational diabetes mellitus
-Placental abruption
-Preterm delivery of a small for gestational age neonate

No significant difference was found in the mode of delivery

Women with panhypopituitarism had a higher risk of developing maternal infection and congenital anomalies but the authors suggest interpreting the results with caution due to the small number of cases.

Feferkorn I, Badeghiesh A, Baghlaf H, et al. Pregnancy outcomes in women with panhypopituitarism: a population-based study. Reprod Biomed Online. 2021;S1472-6483(21)00538-1. doi: 10.1016/j.rbmo.2021.10.018. Epub ahead of print. PMID: 35031238.