New study shows carboxytherapy effective in treating periorbital hyperpigmentation

Carboxytherapy shows promise as an effective and safe treatment for periorbital hyperpigmentation, according to a study.

The study aimed to evaluate the safety and effectiveness of carboxytherapy in treating periorbital hyperpigmentation. Over a 4-week period, 20 patients with symmetric periorbital hyperpigmentation underwent weekly intradermal carboxytherapy sessions. During these sessions, 10-20 mL of CO2 was administered at a controlled rate and temperature. Follow-up assessments were conducted a month after the final session.

The primary outcome measured changes in pigmentation between the orbital and extra-orbital skin before and after the trial. Results showed statistically significant reductions in hyperpigmentation in the lateral, middle, and medial regions of the periorbital area. Patient satisfaction was high, with a total response rate of 20%. Notably, satisfaction levels exceeded the measured changes in pigmentation.

Reference
Seirafianpour F, Atefi N, Amin NG, et al. Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation. Skin Res Technol. 2024;30(3):e13651. doi: 10.1111/srt.13651. PMID: 38483051.