ALP, bilirubin important biomarkers in managing primary biliary cholangitis risk
ALP and bilirubin are considered the most important biomarkers in managing risk in patients with primary biliary cholangitis (PCB), according to an article on RethinkPBC.
Baseline ALP and bilirubin levels and levels at each year for 5 years are strongly associated with clinical outcomes. Elevated levels have been found to impact liver transplant or death.
In one study, ALP >2x ULN was associated with a 2.2x greater risk for liver transplant or death at 1 year compared to those who remained ≤2x ULN. Increased bilirubin levels are associated with increased mortality and reduced transplant-free survival.
More information on predictive biomarkers of primary biliary cholangitis can be found on RethinkPBC.