Is there a heightened risk of HCC among patients with ALGS?

Liver disease severity does not need to be present for hepatocellular carcinoma (HCC) onset in patients with Alagille syndrome (ALGS), according to researchers who suggest a more targeted cancer screening protocol for patients with ALGS.

The full case report and literature review can be found here.

Reference
Schindler EA, Gilbert MA, Piccoli DA, et al. Alagille syndrome and risk for hepatocellular carcinoma: Need for increased surveillance in adults with mild liver phenotypes. Am J Med Genet A. 2021;185(3):719-731. doi: 10.1002/ajmg.a.62028. Epub 2020 Dec 24. PMID: 33369123; PMCID: PMC7898517.