Alagille Syndrome
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Interventional radiology valuable in biliary complications after liver transplantation

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Percutaneous transhepatic cholangiography is a valuable tool in the diagnosis and management of biliary complications after pediatric orthotopic liver transplantation, according to a study.

In this retrospective study, pediatric patients who underwent percutaneous transhepatic cholangiography for the management of biliary complications after orthotopic liver transplantation at a single center were included.

A total of 301 patients underwent orthotopic liver transplantation. Interventional radiology was used to manage 78 patients (26%) who developed biliary complications, which included biliary strictures in 52 (17.3%) patients, bile leaks in 19 (6.3%) patients, biliary stones in 5 (1.7%) patients, iatrogenic biliary obstruction in 1 (0.3%) patient, and vanishing syndrome in 1 (0.3%) patient.

The median time of 6 years between orthotopic liver transplantation and the diagnosis of biliary complications.

All cases were successfully treated with percutaneous transhepatic cholangiography and biliary duct catheterization. There were low complication rates among subgroups.

“Percutaneous treatments in pediatric patients are safe and effective, providing resolution or serving as a bridge to surgery, including re-transplantation,” the authors concluded.

Dulcetta L, Marra P, Carbone FS, et al. Biliary complications in pediatric liver transplantation: findings of percutaneous transhepatic cholangiography in a large single-center cohort. Pediatr Radiol. 2022;doi: 10.1007/s00247-021-05278-3. Epub ahead of print. PMID: 35107594.


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