Blood pressure linked with increased CV risk in children with Alagille syndrome

Carotid intima-media thickness (cIMT) and blood pressure (BP) may help determine which patients with Alagille syndrome (ALGS) or biliary atresia (BA) are at a potentially increase cardiovascular (CV) risk, according to a study.

Vascular parameters were not found to be directly related to lipid abnormalities.

Researchers performed a biochemical assessment on 17 patients with ALGS and 19 with BA, of which 82% and 52.6%, respectively, had abnormal lipid profiles.

In patients with ALGS, there were significantly higher levels of TC, LDL C, APO B, lower glutathione concentration and glutathione peroxidase activity and lower BP, lower cIMT, cIMT-standard deviation scores, and pulse wave velocity.

Reference

Janowski K, Obrycki Ł, Litwin M, et al. Cardiovascular Risk Assessment in Children With Chronic Cholestatic Liver Diseases. J Pediatr Gastroenterol Nutr. 2020 Nov;71(5):647-654. doi: 10.1097/MPG.0000000000002874. PMID: 33093372.