3.229.117.123
dgid:
enl:
npi:0
Hematology
Trending Topics

Inflammation Markers May Predict Poor Outcomes in Patients with Sickle Cell Anemia

Posted on March 31, 2020

More frequent complications in people with sickle cell anemia (SCA) was associated with high blood levels of 2 pro-inflammatory molecules, according to a study published in Annals of Hematology.

Interleukin-6 (IL-6) level was a predictor for poor outcomes and interleukin-8 (IL-8) level was associated with leg ulcer occurrence.

Data obtained from patient interview and medical records was used to study the clinical impact of proinflammatory cytokines interleukin 1-β (IL-1β), IL-6, and IL-8 in patients with SCA. Participants were followed for a median of 18 years (range: 5 to 34 years).

Higher IL-6 levels were associated with higher frequency of vaso-occlusive crisis per year (P = 0.0236), acute chest syndrome (P = 0.01), leg ulcers (P = 0.0001), osteonecrosis (P = 0.0006), stroke (P = 0.0486), and priapism (P = 0.0347) compared to participants who did not experience these complications.

Increased levels of IL-8 was associated with leg ulcers (P = 0.0184).

The authors concluded that “the present study emphasizes the role of inflammation in SCA pathophysiology, reveals an association of IL-8 levels and leg ulcer occurrence, and indicates that IL-6 levels can be used as a useful predictor for poor outcomes in SCA.”

Reference

Domingos IF, Pereira-Martins DA, Sobreira MJVC, et al. High levels of proinflammatory cytokines IL-6 and IL-8 are associated with a poor clinical outcome in sickle cell anemia. Ann Hematol. 2020. DOI: https://doi.org/10.1007/s00277-020-03978-8.

 

-Advertisement-
-Advertisement-
-Advertisement-
-Advertisement-
-Advertisement-
-Advertisement-