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Case Report: Simultaneous Evans Syndrome and Primary Antiphospholipid Syndrome

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In this case report, a 67-year-old man with type 2 diabetes mellitus, hypertension, and renal insufficiency presented with concomitant Evans syndrome (ES), a rare autoimmune disorder in which the person’s own antibodies destroys the body’s red blood cells, white blood cells, and/or platelets, and primary antiphospholipid syndrome (APS).

In 2013, the patient was diagnosed with APS after suffering a deep vein thrombosis of the left lower extremity and started on chronic warfarin. In 2014, he was diagnosed with immune thrombocytopenia (ITP), with a relapse the following year. In addition, the patient was diagnosed with autoimmune hemolytic anemia (AIHA)

The diagnosis of ES was based off his previous episodes of ITP and current AIHA. He was treated with 100 mg prednisone taper. Rituximab was added for complete platelet recovery.

The authors concluded that, “the severe deterioration and rapid recovery with proper treatment of the patient highlights the importance of a timely diagnosis of ES.”

Read the full case report here.

Reference

Patel BP and Jakob J. A rare case of simultaneous evans syndrome and primary antiphospholipid syndrome. Cureus. 2020;12(2):e6845.

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