Customize Consent Preferences

We use cookies to help you navigate efficiently and perform certain functions. You will find detailed information about all cookies under each consent category below.

The cookies that are categorized as "Necessary" are stored on your browser as they are essential for enabling the basic functionalities of the site. ... 

Always Active

Necessary cookies are required to enable the basic features of this site, such as providing secure log-in or adjusting your consent preferences. These cookies do not store any personally identifiable data.

No cookies to display.

Functional cookies help perform certain functionalities like sharing the content of the website on social media platforms, collecting feedback, and other third-party features.

No cookies to display.

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics such as the number of visitors, bounce rate, traffic source, etc.

No cookies to display.

Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.

No cookies to display.

Advertisement cookies are used to provide visitors with customized advertisements based on the pages you visited previously and to analyze the effectiveness of the ad campaigns.

No cookies to display.

3.21.41.164
dgid:
enl:
npi:0
Growth Hormone Deficiency
Journal Scan

How does GH therapy effect cardiac function in children with GHD?

Posted on

Systolic and diastolic function may be impaired in children with Growth Hormone deficiency (GHD) on GH therapy, although parameters may improve after 1 year of treatment, according to a study.

-Advertisement-
-Advertisement-

In this study, researchers 49 children with GHD between the ages of 8-16 years and 49 healthy peers. Children with GHD were divided into 2 groups according to peak GH response <7 μg/L and 7-10 μg/L after 2 GH stimulation tests at baseline, and at 6 and 12 months after therapy initiation.

Left ventricular end diastolic and systolic diameters were significantly lower in children with GHD compared to healthy children, however, within 1 year of treatment both diameters increased significantly, and normal values were achieved.

Tissue Doppler imaging found increased E/A, prolonged isovolumic relaxation time, and shortened ejection time in children with GHD. It also found a significant increase in myocardial performance index in children with GHD compared to healthy children. In the 6th month of treatment, there was a significant improvement in these parameters, although it did not match the parameters in healthy peers. At 1 year, parameters did not match those of healthy children. There was no correlation found between IGF-1 concentration and any echocardiographic parameter.

Reference
Alkan F, Ersoy B, Kızılay DO, et al. Cardiac functions in children with growth hormone deficiency: Effects of one year of GH replacement therapy. Growth Horm IGF Res. 2021;60-61:101432. doi: 10.1016/j.ghir.2021.101432. Epub ahead of print. PMID: 34715474.

-Advertisement-
-Advertisement-
-Advertisement-
-Advertisement-