Thyroid Eye Disease

Psychosocial impact of TED linked to several socioeconomic risk factors

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Patients with thyroid eye disease (TED) are more likely to develop depression and anxiety compared with controls, according to a new study using the nationwide National Institutes of Health All of Us database.

The study compared cases of TED (n = 398) with control cases with matching demographics (n = 1592) for diagnosis of depression or anxiety.

Patients with TED were found to be more likely to have depression and anxiety (P < 0.001) than controls.

Risk factors in patients with TED included:
-Female gender (for both depression and anxiety)
-Unemployment (for anxiety)
-Lower income (for anxiety)

Risk factors for more severe depression (assessed by Patient Health Questionnaire-9 score) and more severe anxiety (assessed by General Anxiety Disorder-7 score) included lower income.

Lee TC, Radha-Saseendrakumar B, Delavar A, et al. Evaluation of Depression and Anxiety in a Diverse Population With Thyroid Eye Disease Using the Nationwide NIH All of Us Database. Ophthalmic Plast Reconstr Surg. 2023;doi: 10.1097/IOP.0000000000002318. Epub ahead of print. PMID: 36727790.